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Dietary Protein Amino acids from legumes and dairy trigger GLP-1 release through amino acid receptors in the gut wall

Understanding these mechanisms helps patients recognize that cold sensitivity is often a normal physiological response to body composition changes rather than a concerning medical problem

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For example, liraglutide, a GLP-1 receptor agonist, improved cognitive function in n = 19 patients with major depressive disorder (MDD) or bipolar disorder in a pilot randomised controlled trial (RCT) [16], whilst a systematic review and meta-analysis reported a pooled reduction in depressive symptoms with GLP-1 receptor agonists compared to other antidiabetic therapies [17]

Patients will need protein-rich meals and resistance exercise to stay strong